Despite The current study aimed to elucidate the antitumor and anticancer effect of taxol extracted from Aspergillus terreus against EAC solid tumor in male Swiss albino mice. Ehrlich solid tumor was inoculated subcutaneously by the concentration of(2 × 10 6)×2.5 ml and after that fungal taxol was injected i.p. by conc. of 2mg/kg BW and continued for 30 days. Fungal taxol has a marked cytotoxic effect against MCF-7 cell line also inhibit KI67 expression in comparison with positive control mice which showed increase of serum ALT and AST activity accompanied by a decline in albumin serum level and also increase in liver tissue homogenate lipid peroxidation (MDA) level was observed, fungal taxol leads to reduction in the mice body weight and both tumor weight and volume in comparison with positive control group and histopathologically fungal taxol has improved the pathological features caused by the oxidative stress induced by EAC solid tumor.