Squamous cell carcinoma antigens (SCCA 1, 2) are members of the ovalbumin serpin family those have been firstly described as biomarkers of squamous cell carcinomas, latterly, different studies have stated the involvement of SCCA in the pathogenesis of certain immunological diseases such as, asthma and atopic dermatitis. Objective: To assess the expression of squamous cell carcinoma antigen 2 in skin of patients with chronic plaque psoriasis and to detect its correlation with the clinical severity of psoriasis and with the density of inflammatory infiltrate in the skin lesions. Methods: Skin biopsies were taken from 24 patients with psoriasis vulgaris and 24 healthy controls by 5 mm punches. Tissues were stained with Hematoxylin and eosin to confirm the diagnosis and to assess the grade of inflammation. The expression level of SCCA2 in the skin was assessed by immune-histochemical analysis .Results: Tissue SCCA 2 level was significantly higher in psoriatic patients than controls and it correlated positively with the severity of psoriasis. In addition, the dermal SCCA 2 expression correlated positively with the density of dermal inflammatory infiltrate. Conclusion: SCCA2 could be a useful marker of the clinical severity and the grade of inflammation of psoriasis