Background: Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe illness have an overactive immune system, which can damage organs other than the lungs. Objective: The aim of this study was to assess the prevalence of clinical manifestations and comorbidities in SARS-CoV-2 infected patients. Patients and methods: This retrospective single-center observational study was conducted in the Tertiary Hospital, Internal Medicine Department, Faculty of Medicine, Zagazig University. This retrospective observational study was conducted on consecutive 370 patients with confirmed SARS-CoV-2 infection from May to September 2020.The diagnosis of the cases was confirmed using RT-PCR for detection of the viral RNA. Demographic characteristics, including underlying comorbidities, symptoms, signs, laboratory findings, chest CT scan and treatment measures were reported. Results: According to this retrospective, single-center observational study, which was conducted on consecutive 370 patients with confirmed SARS-CoV-2 infection? The study involved 193 Egyptian males (52.1%) and 177 Egyptian females (47.9%) with COVID-19. The mean age was 40. 2 ±14.74 years. The common symptoms of the COVID-19 patients at the onset of sickness were myalgia [355 (95.9%)], fatigue [291 (78.6%)], headache [235 (63.5%)], fever [247 (66.8%)], cough [213 (57.6.%)], sputum production [201 (54.3%)] and dyspnea [189 (51.1%)].The most prevalent comorbidity were hypertension [142(38.4%)] followed by diabetes [132 (35.6%)]. Conclusion: The commonest clinical manifestations of confirmed cases of COVID-19 were myalgia, fatigue, headache, fever, and cough and the most prevalent comorbidities associated with COVID 19 patients were hypertension and diabetes.