Anthelminthics are used for trichinellosis elimination in intestine and encysted larvae in muscles. This study evaluated the effects of Nigella sativa, ivermectin versus albendazole on experimental trichinellosis. One hundred and twenty mice were orally infected with 200 larvae of T. spiralis/ mouse. Drugs were tested against mature worms in the small intestine at 7 days post infection (dpi) and encysted larvae at 35 dpi. Parasitological assessment by counting of adult worms and encysted larvae was done as well as histopathologically. Biochemical measuring of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, globulin, and urea, creatinine and creatinine phosphokinase (CPK) values was done. High significant reductions in mean adult count was detected in N. sativa prophylactic, ivermectin and albendazole treated mice with efficacies of 45.9%, 97.4% & 83.6% respectively with mild significant reduction in N. sativa treated mice with percent reduction 26.5%. At 35 dpi, there was high significant reduction in mean larval count as compared to the control infected mice with reduction of 43.7%, 65.3%, 99.4% & 80% in N. sativa prophylactic, N. sativa treated, ivermectin and albendazole respectively. Reduction of AST, ALT, urea, creatinine and CPK levels but total proteins increased in all treated mice compared to corresponding infected non-treated ones. Ivermectin gave the best results and continued for treating T. spiralis. Key words: Trichinellosis, Experimental mice, Treatment