Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti- Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody−Drug Conjugate

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 11135−11144
Authors:
Omnia Ahmed Emam Ismaiel
Journal: Analytical Chemistry American Chemical Society Volume:
Keywords : Multifaceted Bioanalytical Methods , , Comprehensive Pharmacokinetic , Catabolic Assessment    
Abstract:
Herein, we present bioanalytical characterization of the PK and catabolism of a novel ADC. MEDI3726 targets prostate-specific membrane antigen (PMSA) and is comprised of a humanized IgG1 antibody site-specifically conjugated to tesirine (SG
    
     
 
       

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