Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study

Faculty Medicine Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Mei Mohammed Malik Muhammad
Journal: PEDIATRIC LUPUS SAGE Publication Volume:
Keywords : Association , ficolin-2 gene polymorphisms , susceptibility , systemic    
Abstract:
Background Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. Objectives The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions −986 (G/A), −602 (G/A), −4 (A/G) and SNP C/T (rs3124954) located in intron 1, with susceptibility to pSLE in Egyptian children and adolescents. Methods This was a multicenter study of 280 patients diagnosed with pSLE, and 280 well-matched healthy controls. The FCN2 promoter polymorphisms at –986 G/A (rs3124952), −602 G/A (rs3124953), −4 A/G (rs17514136) and SNP C/T (rs3124954) located in intron 1 were genotyped by polymerase chain reaction, while serum ficolin-2 levels were assessed using enzyme-linked immunosorbent assay. Results The frequencies of the FCN2 GG genotype and G allele at −986 …
    
     
 
       

Author Related Publications

  • Mei Mohammed Malik Muhammad, "Occurrence of classes I and II integrons in Enterobacteriaceae collected from Zagazig University Hospitals, Egypt", frontier in microbiology, 2015 More
  • Mei Mohammed Malik Muhammad, "Phenotypic and genotypic characterization of metallo beta lactamases among Gram-negative uropathogens from a tertiary care hospital in Egypt: A cross sectional study التوصيف الظاهري والجيني لإنتاج إنزيمات البيتا لاكتاميز من البكتيريا سالبة الجرام المسببة لعدوى الجهاز البولى فى مستشفى رعاية ثالثية : دراسة مقطعية", Microbes and Infectious Diseases, 2021 More
  • Mei Mohammed Malik Muhammad, "Maintenance of Antibody Response in Egyptian Healthcare Workers Vaccinated with ChAdOx1 nCoV-19 Vaccine during Delta and Omicron Variants Pandemic: A Prospective Study استدامة الاستجابة المناعية للأجسام المضادة لدى العاملين فى القطاع الصحى للمصريين المطعمين بلقاح ChAdOx1 nCoV-19 خلال جائحـة متحورى دلتا وأوميكرون : دراسة إستباقية", Vaccines, 2022 More
  • Mei Mohammed Malik Muhammad, "Susceptibility of carbapenem-resistant Enterobacterales isolates to new antibiotics from a tertiary care hospital, Egypt: A matter of hope حساسية البكتيريا المعوية المقاومة للكاربابينيم للمضادات الحيوية الحديثة في مستشفى رعاية ثالثية بمصر", J Infect Dev Ctries, 2022 More
  • Mei Mohammed Malik Muhammad, "Clinicolaboratory characteristics of pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections: A cross-sectional study الخصائص السريرية والمخبرية لاضطرابات عصبية نفسية مناعية ذاتية لدى الأطفال المرتبطة بعدوى المكورات العقدية (PANDAS)", Microbes and Infectious Diseases, 2023 More

Department Related Publications

  • Fatma Abdelaziz Mossa, "Imipenem resistance and blaimp gene among hospital strains of Pseudomonas aeruginosa at university hospital in Egypt", Journal of Infection in Developing Countries, 2007 More
  • Mei Mohammed Malik Muhammad, "Occurrence of classes I and II integrons in Enterobacteriaceae collected from Zagazig University Hospitals, Egypt", frontier in microbiology, 2015 More
  • Reham Mohamed Elshabrawi Mohamed, "Methicillin Resistant Staphylococcus aureus Antibiotic Profile and Genotypes in Critically Ill Neurosurgery and Medical Oncology Patients", ECRONION, 2016 More
  • Shimaa Abdelaziem Mansur, "Association of cag E Gene and LL-37 Serum Level with Helicobacter pylori-induced Peptic Ulceration in Egyptian Patients", J Medical Microbiol Diagnosis, 2015 More
  • Samar Saied Ali Mosa, "Assessment of Knowledge and Practices of Staff Nurses towards Infectious Diseases Isolation Precautions in Tertiary Care Hospitals: A Multi-Center Study", The egyptian society of community medicine, 2021 More
Tweet