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CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Sarah Mohamed Mahmoud Mahmoud Abedelaal
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Histology Egyptian Journal of Histology
Volume:
Keywords :
CEffect , Silver Nanoparticles Versus Titanium Dioxide Nanoparticles
Abstract:
Background: Silver nanoparticles (Ag-Nps) and Titanium dioxide nanoparticles (TiO2-Nps) are well-known nanoproducts. Both of them have many industrial applications. Lung is one of the major target organs for prolonged nanoparticles exposure. Objective: This study was designed to investigate and compare the possible histopathological toxic effect of Ag-Nps & TiO2- Nps on lung and which of them is safer for future using. Materials & methods: 54 adult male albino rats were divided into 3 equal groups; GroupI (control group), Group II that subdivided into two subgroups; Subgroup IIa: Ag-Nps group with (100 mg/kg/day) daily for 4 successive weeks and Subgroup IIb recovery group left for 4 weeks without injection, Group III that subdivided into two subgroups; Subgroup IIIa: TiO2-Nps group with (150 mg/kg/day) for 4 successive weeks and Subgroup IIIb recovery group left for 4 weeks without injection. Lung specimens were processed for light and electron microscope and immunohistochemical expression of caspase-3 and CD-68. Morphometric and statistical analysis were performed. Results: Group IIa showed collapsed alveoli, others showed ballooned distension and marked thickening of inter-alveolar septa. Extensive cellular infiltration was detected. Group IIIa showed focal areas of collapsed alveoli and thick inter-alveolar septa. Mild cellular infiltrations were observed. Areas of extravasation were detected in the interstitium. Group IIIb showed signs of improvement which is more than group IIb. Conclusion: exposure to Ag-Nps showed marked alterations on histological structure of lung, which is more than the alteration caused by TiO2-Nps; in addition, recovery period was proved to ameliorate these changes better in TiO2-Nps.
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Department Related Publications
Osama Yassen Ibrahim Mohamed, "تسمم الشبكية بعد حقن مركب التراي أمسينولون أسيتونيد داخل الجسم الزجاجي في الأرانب ـ دراسة بالمجهرين الضوئي والالكتروني", لايوجد, 1900
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Azza Saad Ahmed Mahmoud Shehata, "دراسة هستولوجية على الغدة الدرقية و الرحم والمبيض في:IIالفئران المعالجة بالكاربيمازول و الثيروكسين ", لايوجد, 1900
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