PURPOSE: To evaluate the safety and efficacy of retropupillary fixation of an iris-claw intraocular lens (IOL; Verisyse PMMA IOL, Abbott Medical Optics [AMO], Netherlands) for the surgical correction of aphakia in microspherophakic eyes without sufficient capsular support. DESIGN: Prospective interventional non-comparative case series. METHODS: This interventional case series comprised 17 eyes of 9 microspherophakic patients. Retropupillary fixation of the Verisyse iris-claw IOL [AMO] was performed in all cases. The surgical time was measured. Corrected distance visual acuity (CDVA), astigmatism, intraocular pressure, tissue reaction, pigment dispersion and stability of the IOL were studied 1 day, 3 days, 1 week, 2 weeks, 1 month and 6 months postoperatively. RESULTS: Eight patients had familial microspherophakia and one patient had Marfan's syndrome. Eighty-two percent of the cases achieved a visual acuity of 0.3 or better. There was no significant postoperative inflammatory reaction. Transient elevation of IOP was recorded in two cases in the first week only. One IOL developed disengagement of one of the haptics from the iris and was successfully re-engaged. All the other IOLs were well centred and stable. The mean surgical time was 18.0 ± 4.5 min. CONCLUSIONS: Retropupillary fixation of an iris-claw IOL is a safe and effective procedure that provides early visual recovery. It is also a time-saving method for correcting aphakia in microspherophakic eyes without sufficient capsular support.