The current study aimed to identify and investigate the main determinants of pollution haven hypothesis in Middle east and North Africa countries MENA through analyzing number of economic variables like CO2 per capita, FDI per capita, GDP per capita, export, value added, in addition to analyze the interactive effect of institutional variables like corruption, Government effectiveness, political stability, Regulatory Quality, Voice and Accountability. The fixed effect model was applied according to Housman test. The results revealed the positive and significant impact of Economic variables on CO2 emission and it revealed also positive role of institutional variable in Environmental dimension control for FDI.