This study aims to test the determinants of inflation in the Egyptian economy during the period 1990 - 2018 by using the Autoregressive distributed lags model ARDL, the study revealed a Cointegration relationship between the variables based on inflation data, budget deficit, exchange rate, money supply, credit directed to the private sector, Petroleum price and the output gap. The study also showed a positive and significant relationship between inflation and both the exchange rate, output gap and the price of oil, while it didn’t prove the significance of other variables ( budget deficit , money supply and credit directed to the private sector) . So the study recommended the necessity of adopting production strategies that would stimulate exports and reduce imports to positively affect exchange rate and reduce the output gap to control inflation rate.