High positive end-expiratory pressure during ex vivo lung perfusion: recruiting rejected donor lungs

Faculty Medicine Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Kamal Mohamed Salah El Din Mohamed Ayat
Journal: Interactive CardioVascular and Thoracic Surgery Oxford University Press Volume:
Keywords : High positive end-expiratory pressure during , vivo    
Abstract:
We present an innovative method for recruiting clinically rejected donor lungs using positive end-expiratory pressure titration during ex vivo lung perfusion. Currently, ex vivo lung perfusion protocols are using a standard positive end-expiratory pressure of 5 cmH2O for all cases. Individualized positive end-expiratory pressure titration combined with recruitment manoeuvres has been found to significantly improve pulmonary functions in mechanically ventilated patients. Applying this concept to ex vivo lung perfusion may be helpful in increasing the conversion rate for transplant suitability.
    
     
 
       

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