Addition of an adjuvant to local anesthetics improves the quality of nerve block and reduces the need for postoperative opioids intake. The study was aimed to compare the efficiency of dexamethasone versus nalbuphine as perineural additives to local anesthetics mixture in supraclavicular brachial plexus block(BPB). From the results of our study, we can conclude that the addition of 10 mg of nalbuphine hydrochloride or 8 mg of dexamethasone to (bupivacaine 0.5% + Lidocaine 2% 1:1 mixture) BPB has the advantages of prolonging the duration of the sensory block and postoperative analgesia and reduces postoperative opioids requirements without significant hemodynamic instability, with the best result regarding the quality of postoperative analgesia in the nalbuphine group.