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Ascitic non-HDL-C/ HDL-C Ratio: A Novel Prognostic Marker in Liver Cirrhosis
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
30
Authors:
Alsayed Saad Abdelbader Saad
Staff Zu Site
Abstract In Staff Site
Journal:
مجلة علوم الرياضة كلية التربية الرياضية- جامعة المنيا. FACULTY OF MEDICINE ZAGAZIG UNIVERSITY
Volume:
2746-1687
Keywords :
Ascitic non-HDL-C/ HDL-C Ratio: , Novel Prognostic
Abstract:
Background and study aim: Laboratory tests were developed on ascitic fluid for assessing causes, mechanisms, and prognosis of the diseases. This study aimed to evaluate the prognostic value of ascitic lipids in cirrhosis with special consideration to the non-high-density lipoprotein cholesterol (non-HDL-C) and its related ratios. Methods: This cross-sectional study included 120 cirrhotic patients with ascites. Ascitic fluid analysis for lipid contents and calculations of ratios were done. Ascitic lipid contents and ratios are used to assess liver disease severity and predict the mortality in patients groups with different Child-Pugh classes. Results: Regarding Child-Pugh score, ascitic cholesterol, and HDL-C showed significantly higher levels in group Cwhen compared to groups A and B. Ascitic non-HDL-C and ascitic non-HDLC/ HDL-C ratio had a statistically significant increasing trend among ChildPugh groups. Serum-ascites cholesterol gradient showed no significant difference among Child-Pugh groups (p>0.05). Ascitic non-HDL-C/ HDL-C ratio had the highest positive linear correlation with cirrhosis severity scores (p<0.0001). High ascitic non-HDL-C/ HDL-C ratio patients had a higher mortality rate when compared to those with a lower ratio (38.5% versus 9.5%). Conclusion: Ascitic non-HDL-C/HDL-C ratio was more beneficial than non-HDLC level in cirrhosis severity prediction. Also, it could predict the cirrhotic patients' survival. So, Ascitic non-HDLC/HDL-C ratio seems to be an excellent prognostic marker for cirrhosi
Author Related Publications
Alsayed Saad Abdelbader Saad, "A study of the Role of 25 Hydroxy-Cholecalciferol Level on Non Alcoholic Fatty Liver Disease (NAFLD) in a Cohort of Egyptian Patients", faculity of medicine zagazig university, 2018
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Alsayed Saad Abdelbader Saad, "Evaluation of HCV-associated Hepatocellular Carcinoma Based on Alpha-fetoprotein Levels", faculity of medicine zagazig university, 2020
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Alsayed Saad Abdelbader Saad, "Current evaluation of sepsis among patients with liver cirrhosis", faculity of medicine zagazig university, 2018
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Alsayed Saad Abdelbader Saad, "Brucellosis Relapse: A Retrospective Study of Risk Factors among Saudi Patients", faculity of medicine zagazig university, 2018
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Alsayed Saad Abdelbader Saad, "IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt", faculity of medicine zagazig university, 2020
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Department Related Publications
Ashraf Metwally Abdulfatah, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Amal AbdelFattah Gouda Msthry, "Risk of Hepatic Encephalopathy in Diabetic Decompensated Liver Diseased Patients with Post- HCV Liver cirrhosis", كلية الطب جامعة الزقازيق, 2015
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Hossam Mohamed Sayed Mouhammid, "Restrictive versus Liberal Blood Transfusion Strategies in Egyptian Patients with Esophageal Variceal Bleeding", http://www.scirp.org/journal/ojgas, 2016
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Ahmed Mohamed Algebaly Ahmed Kammil, "The association between interleukin‐21 (rs2055979G/T) gene polymorphism and the risk of hepatocellular carcinoma and metastasis in patients with hepatitisCvirus", Journal of CELLULAR BIOCHEMISTRY, 2019
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Ahmed Saied Mohamed Ibrahem, "A Prospective Study of the Role of Antibiotic Prophylaxis in Compensated Cirrhotic Patients after the First Variceal Bleeding", hepatology, gastroentrology & infectious diseasese, faculty of medicine, Zagazig university, 2024
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جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف