Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrileas a precursor for the synthesis of some novel pyrimidines: antibacterial activity

Faculty Science Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Atef Mohamed AbdelHamid Ali Hassn
Journal: Journal of the iranian chemical society springer Volume:
Keywords : Utility , 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrileas , precursor , , synthesis , some novel    
Abstract:
The starting material 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile 3 was reacted with various reagents resulting in the formation of a group of new pyrimidines and condensed pyrimidines including quinazoline 6 tetrazolopyrimidine 12, pyrazolopyrimidines 14, 18, and 19, triazolopyrimidine 16, and pyrimidopyridazine 20. The antibacterial activity was evaluated for a group of the synthesized compounds against examples of Gram-positive and Gram-negative bacteria.
    
     
 
       

Author Related Publications

  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Atef Mohamed AbdelHamid Ali Hassn, "synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines", elsevier, 2017 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives", Science Publishing Corporation, 2012 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Utility of 6-Aryl-5-Cyano-2-Thiouracil Derivative as a Precursor for the Synthesis of Some New Pyrimidines", scientific & academic publishing, 2013 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Intermolecular cyclization of cinnamoylisothiocyanate: A new synthetic entry for pyrimidine, triazine, and triazole candidates", Taylor & Francis, 2018 More

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