Objective This study aimed to evaluate the results of partial laryngotracheal resection and anastomosis in the management of iatrogenic laryngotracheal stenosis. Patients and methods This retrospective analytical study was conducted on all patients who had been operated by means of partial laryngotracheal resection and anastomosis in our institute, from 2004 to 2014. The period of follow-up was at least 1 year. The total number of the patients included was 22. Results Successful decanulation was achieved in 20 (90.9%) cases. The number of complicated cases in our study (with one or more complication) was eight (36.3%). Two cases complained of dyspnea with documented restenosis of the trachea, and one case died from severe hemoptysis at 12 days postoperatively, most probably from trauma of the innominate. Two cases were complicated by surgical emphysema and one case was complicated by hematoma; all of them were managed successfully. Conclusion Partial laryngotracheal resection and anastomosis is a safe and reliable surgical method for the management of grade III and IV iatrogenic laryngotracheal stenosis. This technique achieves best results in male patients when the stenosis is short segment, and not involving the cricoid cartilage.