Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
The roleofneuralprecursorcell-expresseddevelopmentally down-regulated protein9inpredictingbacillusCalmette-Guerin response innonmuscleinvasivebladdercancer
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Amro Mohamed Fawzy Ibrahiem Eldesouky
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of infection in developing countries Elsevier
Volume:
Keywords :
, roleofneuralprecursorcell-expresseddevelopmentally down-regulated protein9inpredictingbacillusCalmette-Guerin response innonmuscleinvasivebladdercancer
Abstract:
Objective: To reportthesensitivityandspecificity ofneuralprecursorcell-expresseddevelopmentallydown-regulatedprotein9 (NEDD9) proteinhighexpressioninpredictingBCGresponseanditseffectonrecurrenceorprogressionfreesurvivals. Patients andmethods: Between May2014andApril2017,aprospectivecohortstudywasconductedon105patientswithintermediate or high-risknonmuscleinvasivebladdercancer.Immunohistochemicalstainingwithmousemonoclonalanti-NEDD9antibodywasdone. Examination oftheslideswasdonetodetectNEDD9cytoplasmicexpression.IntravesicalinductionbacillusCalmette-Guerin(BCG) instillation therapywasstartedforallpatients2to4weeksafterendoscopywithonceweeklyinstillationfor6weeks.Intravesical maintenance BCGinstillationwasthencontinuedevery3monthsforatleast1year.Followupwithcystoscopyevery3monthsfor2years and every6monthsafterthat. Results: The meanage ± SD ofthepatientswas57 ± 4.5 years.Themedianfollow-upperiodwas25(12–36) months.NEDD9protein was highlyexpressedin61(58.1%)patients,whereaslowexpressionwasin44(41.9%)patients.Sensitivityandspecificity ofNEDD9high expression inpredictingrecurrencewere83.6%and64.2%,respectively.Itssensitivityandspecificity inpredictingprogressiontomuscle invasion ordistantmetastaseswere91.3%and51.2%,respectively.Itssensitivityandspecificity inpredictingcompleteresponsetoBCG therapy were84.1%and80.9%.Kaplan-Meiertestshowedhighlysignificant difference(P o 0.0001) insurvivalwithoutrecurrenceor progression betweenpatientsshowinghighexpressionandthoseshowinglowexpression. Conclusion: NEDD9 proteintissuemarkercouldbeusedasapredictivemarkerforBCGresponseinnonmuscleinvasivebladdercancer with reasonablesensitivityandspecificity.
Author Related Publications
Amro Mohamed Fawzy Ibrahiem Eldesouky, "Minimally invasive percutaneous nephrolithotomy vs standard PCNL for management of renal stones in the flank-free modified supine position: single-center experience", Springer, 2017
More
Amro Mohamed Fawzy Ibrahiem Eldesouky, "Flank free modified supine position: A new modification for supine percutaneous nephrolithotomy", Elsevier, 2012
More
Amro Mohamed Fawzy Ibrahiem Eldesouky, "Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study", Elsevier, 2016
More
Amro Mohamed Fawzy Ibrahiem Eldesouky, "The prognostic significance of p53, p63 and her2 expression in non-muscle-invasive bladder cancer in relation to treatment with bacille Calmette–Guerin", Elsevier, 2015
More
Amro Mohamed Fawzy Ibrahiem Eldesouky, "Immediate versus delayed shockwave lithotripsy for inaccessible stones after uncomplicated percutaneous nephrolithotomy", ElSEVIER, 2017
More
Department Related Publications
Mahmoud Mohamed Mahmoud Eladl, "Immunologic Factors in Recurrent Urinary Calculi of Bilharzial patients", Zagazig university medical journal, 1983
More
Essam Abdelmohsen Mahmoud Desouky, "TRANSPERITONEAL VERSUS RETROPERITONEAL LAPAROSCOPIC NEPHRECTOMY FOR BENIGN NONFUNCTIONG KIDNEY", Egyptian Journal of Urology, 2014
More
Essam Abdelmohsen Mahmoud Desouky, "Sildenafil in combination with tamsulosin versus tamsulosin monotherapy for management of male LUTS due to BPH: A randomized, doubleblind trial.", Arab Journal of Urology, 2017
More
Emad Abdelhamied Hassan Salem, "Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study", Arab Journal of Urology, 2017
More
Ahmed Alayman Abdelaal Ahmad, "دور جراحة دوالى المجهرية تحت الفتحة الاربعية الخارصية فى تقليل مضاعفات الجراحة التقليدية", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف