Background: The use of technology and computers in health care has been reported to improve nurses’ decision-making and competencies which in turn increase the quality of health-care practice. Aim of the study: To assess nursing students’ self-efficacy and attitudes toward computer use in health care. Research Design descriptive comparative cross-sectional study design was used. Study Setting: The study was conducted in faculty of nursing - Banha University, Egypt and faculty of nursing – Hail University, Kingdom of Saudi Arabia. Sample: quota sampling of 219 students were chosen as follow; 190 students from Faculty of nursing - Banha University and 29 students from Faculty of Nursing – Hail University. Tools of data collection: A structured self-administered questionnaire covering socio-demographic data, the Pretest for Attitudes toward Computers in Healthcare, and computer self-efficacy scales. Results: the total number of nursing students was 219; 190 From Faculty of Nursing Benha University and 29 from Hail University. In relation to their age, the majority of both of them (95%, 72%) were aged less than 25years old respectively. Regarding their gender the majority of Behan students were females (71%) while all of Hail students were females (100%). Regarding to their education the majority of both of them (75%, 55%) had high school (Regular) respectively.as well as all Benha and Hail nursing students (100%) were studied computer before. While, more than two third (62%) of Benha students studied it in high school and, more than two third (66%) of Hail nursing students had studied computer before in college/ preparatory year. Regarding the workshops the majority of both of them (83, 86%) had 1 to 5 workshops respectively.in relation to years of experience in uses computers the majority of both of them(46%,66%) had from 5 to 10 years of experience. Overall. There was no significant difference was observed among nursing students in both faculties regarding their personal characteristics except in items related to years of experience in using computer (P Value = 0.025). 33 % of nursing students from Benha University have realistic view of current computer capabilities in health care while 28% of nursing students from Hail were have very positive view of computer use in health care. Nursing students at Hail University have the highest mean score compared with Benha nursing students (79.45 ± 15.85 & 61.2±7.25, respectively) in their attitudes toward computer and computer self-efficacy. Benha nursing students have moderate computer self-efficacy compared with Hail nursing students who have high computer self-efficacy level. Highly statistical significant relation was detected between students attitudes toward computers and computer self-efficacy (P Value= 0.000). In addition, there was highly positive statistical significant correlation between the demographic variables of the students and both students’ attitude toward computer in health care and computer self-efficacy (p value =0.00). Conclusion: Nursing students in both universities have positive attitude toward computer use with a significant difference in the mean scores of the two groups in their attitude toward computer use and their computer self-efficacy. Hail nursing students have reported high computer self-efficacy level compared with Benha students. In addition, a statistical significant correlation between the studied variables has been also detected. Recommendations: Further studies are recommended regarding evaluations on existing technologies in terms of acceptance, effectiveness and efficiency in real-life settings and to examine its effect on patient outcomes. In addition, nurse educators should design training courses and educational programs to enhance computer self-efficacy beliefs among nursing students.