Abstract: Background: Patients on hemodialysis (HD) may experience troubling symptoms, which cause daily distress and negatively affects their quality of life (QoL). Aim of the study: The study aim was to assess the psychological problems such as fatigue, depression and sleep disturbance among HD patients. Research Design: This descriptive cross-sectional. Study Setting: study was carried out in the HD units at the General and Fevers Hospitals in Zagazig City Study Sample: on 105 adult patients on HD. Tools of data collection: The data collection tool consisted of an interview form, which included a Sleep Disturbance Scale, Beck Depression Inventory (BDI) scale, and the Fatigue Severity Scale (FSS) of sleep disorder. Results: The study findings revealed that more than half of the patients were male (54.3%), age 50 years or older (50.5%), illiterate (57.1%), and working (54.3%). Overall, 90.5% of the patients had sleep problems and 83.8% had fatigue symptoms; 37.1% and 33.3% had severe and moderate depression symptoms respectively. Patient’s age, income, marital status, and duration of illness have significant influences on these disorders. Conclusion:Hence, these patients need psychological support in order to relieve these symptoms and prevent their untoward effects on their health and wellbeing. Recommendations: Further research is proposed to test the effectiveness of nursing interventions in decreasing depression and fatigue symptoms, and improving the quality of sleep among HD patients Keywords: Hemodialysis, Depression, Fatigue, Sleep disorders