Background: Invasive ductal carcinoma is a common and fatal breast cancer. It is important to detect recent prognostic biomarkers and therapeutic targets for better risk stratification and management of such cancer type. SLUG, is a transcription factor and a Snail family member, which plays a vital role in Epithelial-mesenchymal transition [EMT] activation in cancer cells. YKL-40 is also named chitinase-3-like-1 and its aberrant expression was detected in a variety of cancers. Results about clinicopathological and prognostic roles of combined SLUG & YKL-40 expression in invasive ductal carcinoma of the breast still needs clarifications. Aim of the work: To assess SLUG & YKL-40 expression in invasive ductal carcinoma of the breast tissue, and to correlate their combined expression with clinicopathological parameters of the tumor. Methods: SLUG& YKL-40 expression was evaluated in sections from sixty paraffin blocks that were previously diagnosed as invasive ductal carcinoma of the breast of different grades, stages and molecular subtypes using immunohistochemistry. Then associations between their expressions levels, clinic-pathological parameters of our cases were analyzed. Results: SLUG high expression was associated with older age of the patients (p=0.002), higher grade (p=0.003), presence of lymph node metastases (p=0.009), advanced stage (p= < 0.001) presence of distant metastases (p=0.011), negative ER (p=0.004), & PR (p=0.005) hormonal receptors positivity, aggressive molecular subtype, (p= < 0.001). YKL-40 high expression was associated with older age of the patients (p = 0.008), higher grade (p=0.007), presence of lymph node metastases (p=0.03), advanced stage (p= < 0.001), presence of distant metastases (p=0.021), negative ER (p=0.004), & PR (p = 0.007) hormonal receptors positivity, aggressive molecular subtype, (p=0.004).