Chemical and biological studies on charge-transfer complexes of cimetidine with various electron acceptors

Faculty Specific Education Year: 2019
Type of Publication: ZU Hosted Pages: 255-268
Authors:
Akmal Shawky Gaballa
Journal: Bull. Chem. Soc. Ethiop. Elsevier B.V. Volume:
Keywords : Chemical , biological studies , charge-transfer complexes of cimetidine    
Abstract:
Interaction of Cimetidine drug (CIM) with p-acceptors as Tetracyanoethylene (TCNE) and 7,70,8,80-Tetracyanoquinodimethane (TCNQ), chloranilic acid (H2CA) picric acid (HPA) resulted through the initial formation of ionic intermediate to charge transfer (CT) complex which detected by spectroscopic studies. The molar ratio was found to be 1:1 between cimetidine drug and different acceptor. The formed CT complexes have been characterized using various techniques such as the elemental analyses, UVeVis., IR, and 1H NMR spectra, and thermal analyses (TG, DTG). The antibacterial activity of the complexes were estimated.
    
     
 
       

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