Role of mannose binding lectin in response to candida antigen immunotherapy of warts

Faculty Medicine Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Iman Salah El-Shahat Mustafa Gharbaoui
Journal: JOURNAL OF DERMATOLOGICAL TREATMENT talyor &francis Volume:
Keywords : Role , mannose binding lectin , response , candida    
Abstract:
A case-control study was enrolled with 96 participants; 48 wart cases and 48 healthy controls. MBL serum level assay baseline and after six settings of intralesional candida antigen injection was done by ELISA technique. MBL2 gene exon 1 codon 54 polymorphism was detected by using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Results: A statistically significant difference in MBL serum level between wart cases and controls was found. An association between MBL2 exon1 codon 54 polymorphism and susceptibility to HPV infection and development of warts was proved. Carriage of genotype AB was more frequent wart cases (95.8%) than in controls (20.8%). No statistical significance association could be found between the therapeutic response to Candida antigen immunotherapy in wart cases and MBL as regards its serum level and genotypes.
    
     
 
       

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