X-ray crystal structure of a 2-amino-3, 4-dihydroquinazoline 5-HT3 serotonin receptor antagonist and related analogs

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 761-770
Authors:
Ahmed Samy Abdelsamad Abdelkhalek hilal
Journal: Poultry Science international Volume: 98
Keywords : X-ray crystal structure , , 2-amino-3, 4-dihydroquinazoline 5-HT3    
Abstract:
Certain 2-amino-3,4-dihydroquinazolines bind at 5-HT3 serotonin receptors and act as antagonists (e.g. 6-chloro) whereas others bind with little to no affinity and lack functional activity (e.g. 8-chloro). The purpose of this investigation
   
     
 
       

Author Related Publications

  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "SYNTHESIS AND EVALUATION OF 2, 3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS", international, 2013 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Synthesis and biological screening of new derivatives of 2,3-dihydro quinazolin-4(1H)-one and benzotriazepin- 5(2H)-one for central nervous system activity", international, 2014 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "“Methylene Bridge” to 5-HT3 Receptor Antagonists Conformationally Constrained Phenylguanidines", American Chemical Society, 2018 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Probing of 2-Amino-6-Chloro-3,4-Dihydroquinazoline Hydrochloride At 5- HT3 Receptor", Scholars Research Library, 2018 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Probing of 2-Amino-6-Chloro-3,4-Dihydroquinazoline Hydrochloride At 5- HT3 Receptor", Scholars Research Library, 2018 More

Department Related Publications

  • Mansour Alsayed Mansour Abokol, "SPECTROPHOTOMETRIC DETERMINATION OF KETOPROFEN IN PHARMACEUTICAL PREPARATIONS BY MEANS OF CHARGE TRANSFER COMPLEXES", Talnta. Vol. 40. No. 4 pp. 585-588, 1993 More
  • Mansour Alsayed Mansour Abokol, "REACTION OF 2, 3- DICHLOROMALEIC ANHYDRIDE I: NITROSATIVE REDUCTIVE ELIMINATION; SYNTHESIS OF N-(2,6-DIMETHYLPHENYL)-2-(N-NITROSO-N-SUBSTITUTED)AMINO- SUCCINIMIDES", Chim. Farmaceutico – Anno 135 –pp.429-433 n. 7 Luglio/Agosto, 1996 More
  • Mansour Alsayed Mansour Abokol, "UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLOINES AND RELATED COMPOUNDS", Mansour E.Abou Kull. Zagazig J.Pharm.sci., Dec.(1999) Vol.8 No.2, p13-17, 1999 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Eco-friendly novel deconvoluted synchronous spectrofluorimetric approach for the determination of favipiravir, levodropropizine and moxifloxacin hydrochloride as an effective therapeutic combination for COVID-19; application in laboratory prepared mixtures and spiked human plasma", Elsevier, 2023 More
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