X-ray crystal structure of a 2-amino-3, 4-dihydroquinazoline 5-HT3 serotonin receptor antagonist and related analogs

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 761-770
Authors:
Ahmed Samy Abdelsamad Abdelkhalek hilal
Journal: Poultry Science international Volume: 98
Keywords : X-ray crystal structure , , 2-amino-3, 4-dihydroquinazoline 5-HT3    
Abstract:
Certain 2-amino-3,4-dihydroquinazolines bind at 5-HT3 serotonin receptors and act as antagonists (e.g. 6-chloro) whereas others bind with little to no affinity and lack functional activity (e.g. 8-chloro). The purpose of this investigation
   
     
 
       

Author Related Publications

  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "SYNTHESIS AND EVALUATION OF 2, 3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS", international, 2013 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Synthesis and biological screening of new derivatives of 2,3-dihydro quinazolin-4(1H)-one and benzotriazepin- 5(2H)-one for central nervous system activity", international, 2014 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "“Methylene Bridge” to 5-HT3 Receptor Antagonists Conformationally Constrained Phenylguanidines", American Chemical Society, 2018 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Probing of 2-Amino-6-Chloro-3,4-Dihydroquinazoline Hydrochloride At 5- HT3 Receptor", Scholars Research Library, 2018 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Probing of 2-Amino-6-Chloro-3,4-Dihydroquinazoline Hydrochloride At 5- HT3 Receptor", Scholars Research Library, 2018 More

Department Related Publications

  • Mahmoud Mohamed Mohamed Sebaee, "Rapid RP-HPLC Method for Simultaneous Estimation of Some Antidiabetics; Metformin, Gliclazide and Glimepiride in Tablets", ejchem.journals.ekb.eg, 2018 More
  • Rania Hamdy Ahmed Badawi, "Design, synthesis, and computational validation of novel compounds selectively targeting HER2-expressing breast cancer", Elsevier, 2020 More
  • Mahmoud Mohamed Mohamed Sebaee, "Toxicity Profile and Pharmacokinetic Study of Antibiotic Mixtures, Gentamicin and Vancomycin, in Rat Plasma by Ecofriendly Liquid Chromatography Coupled Tandem Mass Spectrometry", acs publications, 2020 More
  • Mohammed Mohamed Mahmoud Baraka, "Toxicity Profile and Pharmacokinetic Study of Antibiotic Mixtures, Gentamicin and Vancomycin, in Rat Plasma by Ecofriendly Liquid Chromatography Coupled Tandem Mass Spectrometry", acs publications, 2020 More
  • Sobhi Mohamed Mahmoud Ibrahym, "Toxicity Profile and Pharmacokinetic Study of Antibiotic Mixtures, Gentamicin and Vancomycin, in Rat Plasma by Ecofriendly Liquid Chromatography Coupled Tandem Mass Spectrometry", acs publications, 2020 More
Tweet