“Methylene Bridge” to 5-HT3 Receptor Antagonists Conformationally Constrained Phenylguanidines

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Samy Abdelsamad Abdelkhalek hilal
Journal: ACS Chemical Neuroscience American Chemical Society Volume:
Keywords : “Methylene Bridge” , 5-HT3 Receptor Antagonists Conformationally    
Abstract:
Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroqui
    
     
 
       

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  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Synthesis and biological screening of new derivatives of 2,3-dihydro quinazolin-4(1H)-one and benzotriazepin- 5(2H)-one for central nervous system activity", international, 2014 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Probing of 2-Amino-6-Chloro-3,4-Dihydroquinazoline Hydrochloride At 5- HT3 Receptor", Scholars Research Library, 2018 More
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  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "X-ray crystal structure of a 2-amino-3, 4-dihydroquinazoline 5-HT3 serotonin receptor antagonist and related analogs", international, 2020 More

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  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and biological activity of 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives", Elsevier, 2007 More
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