Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex

Faculty Science Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: ChemBioChem Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Volume:
Keywords : Cyano Modification , Uridine Decreases Base-Pairing Stability , Specificity    
Abstract:
5-Cyanomethyluridine (cnm5U) and 5-cyanouridine (cn5U), the two uridine analogues, were synthesized and incorporated into RNA oligonucleotides. Base-pairing stability and specificity studies in RNA duplexes indicated that cnm5U slightly
    
     
 
       

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