1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: bioorganic chemistry elsevier Volume:
Keywords : 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives , anti-inflammatory , analgesic agents    
Abstract:
The design and synthesis of a new series of 1,4-dihydroquinazolin-3(2H)-yl benzamide derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are reported. The target compounds (4a–o) were synthesized using a tw
    
     
 
       

Author Related Publications

  • Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016 More
  • Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013 More

Department Related Publications

  • Samar Abdelmigeed Mohamed Rezk, "Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats.", USA, 2016 More
  • Mona Fouad Mahmoud Abdelaziz, "Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors", Naunyn-Schmiedeberg's archives of pharmacology, 2016 More
  • Mona Fouad Mahmoud Abdelaziz, "Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Seipin deficiency leads to defective parturition in mice", Oxford University Press, 2017 More
Tweet