Design, synthesis and biological evaluation of novel quinazoline-2,4- diones conjugated with different amino acids as potential chitin synthase inhibitors

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: European Journal of Medicinal Chemistry elsevier Volume:
Keywords : Design, synthesis , biological evaluation , novel quinazoline-2,4- diones    
Abstract:
A series of (2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl) acetamido) acids) (6 a-m), (7) has been designed to inhibit the action of fungus chitin synthase enzyme (CHS). The synthesis of the designed compounds was carried out in fou
    
     
 
       

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  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
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  • Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013 More

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