Design, synthesis and biological evaluation of novel quinazoline-2,4- diones conjugated with different amino acids as potential chitin synthase inhibitors

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: European Journal of Medicinal Chemistry elsevier Volume:
Keywords : Design, synthesis , biological evaluation , novel quinazoline-2,4- diones    
Abstract:
A series of (2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl) acetamido) acids) (6 a-m), (7) has been designed to inhibit the action of fungus chitin synthase enzyme (CHS). The synthesis of the designed compounds was carried out in fou
    
     
 
       

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  • Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016 More
  • Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013 More

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  • Mohammed Alhuseiny Abdelhamid Elsadek , "Exploring the binding sites of Staphylococcus aureus phenylalanine tRNA synthetase: A homology model approach", www.elsevier.com/locate/JMGM, 2017 More
  • Nada Abdasattar mohamed Noureddine, "Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives", Wiley, 2017 More
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  • Alsayed Mohamed Mansour Lashen , "Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives", Wiley, 2017 More
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