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Insulin Resistance and Portal Hemodynamic Changes before and after Treatment with New Direct Antiviral Drugs in Chronic Hepatitis C.
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Ibrahim Mohammed Ibrahim Ahmed
Staff Zu Site
Abstract In Staff Site
Journal:
Afro-Egypt J Infect Endem Dis Afro-Egypt J Infect Endem Dis
Volume:
Keywords :
Insulin Resistance , Portal Hemodynamic Changes before
Abstract:
Background and study aim: Insulin resistance is typically associated with chronic hepatitis C virus and its improvement after treatment of HCV with new direct antiviral drugs may change portal hemodynamics. This study aimed at assessing changes in HOMA-IR, APRI score and platelet count/spleen diameter ratio as fibrotic markers and changes of portal hemodynamics after treatment with direct- acting antiviral drugs. Patients and Methods: The Study included 100 chronic HCV patients who were eligible for treatment with directacting antiviral drugs. HOMA-IR, APRI score and platelet count/ spleen diameter ratio and changes of portal hemodynamics were calculated. Results: The noninvasive indices of liver fibrosis were assessed before and after HCV treatment. Insulin resistance improved significantly after treatment from (3.2±0.9) to (2.9±0.7). Doppler parameters of the studied group also showed marked improvement after treatment where the portal vein flow velocity and flow volume increased (15.8 ±1.7 vs 16.1±1.3) and (728.3±128.2 vs 1059.9±29.6) respectively. Hepatic artery resistive index and calculated congestive index of portal vein also, showed improvement (0.6±0.1 vs 0.49±0.1) (0.077 ±0.014 vs 0.051 ± 0.017) respectively. Conclusion: Direct-acting antiviral drugs may reduce inflammatory and fibrotic sequelae of HCV infection. Also, portal hypertensive indices improved and HOMA IR, APRI score and platelet count/splenic diameter ratio show improvement.
Author Related Publications
Ibrahim Mohammed Ibrahim Ahmed, "The Usefulness of Ascitic Fluid Lactoferrin Level in Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients.", Afroegyptian journal of endemic diseases, 2025
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Ibrahim Mohammed Ibrahim Ahmed, "تحسين تشخيص تضيق القناة الصفراوية البعيدة: التصوير بالموجات فوق الصوتية بالمنظار للكشف عن الكتل غير المكتشفة في التصوير المقطعي", Afroegyptian journal of endemic diseases, 2025
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Ibrahim Mohammed Ibrahim Ahmed, "Large Balloon Dilatation Versus Endoscopic Complete Sphincterotomy in Patients with Large Common Bile Duct Stone(s) and Periampullary Diverticulum.", Egyptian Liver Journal, 2025
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Ibrahim Mohammed Ibrahim Ahmed, "Frequency and characterization of mixed ascites among cirrhotic patients admitted to Zagazig University hospital.", Medical Journal of Viral Hepatitis, 2020
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Ibrahim Mohammed Ibrahim Ahmed, "Microscopic Colitis in Patients with Unexplained Chronic Watery nonBloody Diarrhea: A Cross Sectional Study", Open Journal of Gastroenterology, 2020
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Department Related Publications
Ashraf Metwally Abdulfatah, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Amal AbdelFattah Gouda Msthry, "Risk of Hepatic Encephalopathy in Diabetic Decompensated Liver Diseased Patients with Post- HCV Liver cirrhosis", كلية الطب جامعة الزقازيق, 2015
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Sameh Mahmoud Abdelmoneim Mahmud, "Different Factors Correlated to Early Rebleeding in Cirrhotic Patients Treated by Variceal Band ligation versus Endoscopic Sclerotherapy", المجلة الافريقية المصرية للأمراض المعدية والمتوطنة, 2016
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