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Insulin Resistance and Portal Hemodynamic Changes before and after Treatment with New Direct Antiviral Drugs in Chronic Hepatitis C.
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Ibrahim Mohammed Ibrahim Ahmed
Staff Zu Site
Abstract In Staff Site
Journal:
Afro-Egypt J Infect Endem Dis Afro-Egypt J Infect Endem Dis
Volume:
Keywords :
Insulin Resistance , Portal Hemodynamic Changes before
Abstract:
Background and study aim: Insulin resistance is typically associated with chronic hepatitis C virus and its improvement after treatment of HCV with new direct antiviral drugs may change portal hemodynamics. This study aimed at assessing changes in HOMA-IR, APRI score and platelet count/spleen diameter ratio as fibrotic markers and changes of portal hemodynamics after treatment with direct- acting antiviral drugs. Patients and Methods: The Study included 100 chronic HCV patients who were eligible for treatment with directacting antiviral drugs. HOMA-IR, APRI score and platelet count/ spleen diameter ratio and changes of portal hemodynamics were calculated. Results: The noninvasive indices of liver fibrosis were assessed before and after HCV treatment. Insulin resistance improved significantly after treatment from (3.2±0.9) to (2.9±0.7). Doppler parameters of the studied group also showed marked improvement after treatment where the portal vein flow velocity and flow volume increased (15.8 ±1.7 vs 16.1±1.3) and (728.3±128.2 vs 1059.9±29.6) respectively. Hepatic artery resistive index and calculated congestive index of portal vein also, showed improvement (0.6±0.1 vs 0.49±0.1) (0.077 ±0.014 vs 0.051 ± 0.017) respectively. Conclusion: Direct-acting antiviral drugs may reduce inflammatory and fibrotic sequelae of HCV infection. Also, portal hypertensive indices improved and HOMA IR, APRI score and platelet count/splenic diameter ratio show improvement.
Author Related Publications
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Department Related Publications
Amal AbdelFattah Gouda Msthry, "Serum Neoptrin Level as a Marker for Activity in Chronic Hepatitis B Virus Infection", كلية الطب جامعة القاهرة, 2016
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Sherif Mohamed Galal Mahdy, "Hyponatremia In Patients With Liver Cirrhosis And Its Association To The Severity of Hepatic Decompensation", المجلة المصرية لأمراض الجهاز الهضمي والكبد والأمراض المعدية, 2013
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Maysa Abdullah Saeed Muhmd, "Gastrointestinal Basidiobolomycosis: An Emerging, and A Confusing, Disease in Children (A Multicenter Experience)", Thiem Medical Publishers Inc., 2018
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Ehab Mohamed Ibrahiem Darwesh, "Detection of Parasites During Upper Gastrointestinal Endoscopic Procedures", Afro-Egypt J Infect Endem Dis, 2012
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Soha Abdelmoniem Mohamed Khallil, "Microwave Ablation and/or Transcatheter Arterial Chemoembolization in the Treatment of Hepatocellular Carcinoma", Afro-Egypt J Infect Endem Dis, 2020
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