Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2- amines as Bcl-2 inhibitory anticancer agents

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Alsayed Mohamed Mansour Lashen
Journal: Bioorganic & Medicinal Chemistry Letters Elsevier Volume:
Keywords : Synthesis , evaluation , 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2- amines , Bcl-2 inhibitory anticancer    
Abstract:
A series of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines 8a–j has been designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2-inhibitory anticancer agents based on our previous lead compound 8a. Synthesis of the t
    
     
 
       

Author Related Publications

  • Alsayed Mohamed Mansour Lashen , "Synthesisis Of Certain Condensed Pyrimidines", لايوجد, 1900 More
  • Alsayed Mohamed Mansour Lashen , "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Alsayed Mohamed Mansour Lashen , "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Alsayed Mohamed Mansour Lashen , "Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives", Wiley, 2017 More
  • Alsayed Mohamed Mansour Lashen , "Exploring the binding sites of Staphylococcus aureus phenylalanine tRNA synthetase: A homology model approach", www.elsevier.com/locate/JMGM, 2017 More

Department Related Publications

  • Mansour Alsayed Mansour Abokol, "SYNTHESIS OF 3- SUBSTITUTED (6-BROMO-2-IMIDAZO {4, 5- B} PYRIDINYL) PROPIONIC ACID AS ANTIINFLAMMATORY, ANALGESIC, AND ANTIPYTRIC AGENTS", Zag. J. Pharm. Sci., Vol. 1 No. 1 Nov. Pp 129-139 June, 1993 More
  • Mahmoud Mohamed Mohamed Sebaee, "Developing a High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma", benthamscience, 2020 More
  • Noha Ibrahiem Elsayed Mohamed Zidain, "Developing a High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma", benthamscience, 2020 More
  • Sobhi Mohamed Mahmoud Ibrahym, "47. Hplc determination of three cephalosporines (cefipime, ceftriaxone , cefotaxime) in their bulk and dosage form", Asian J .Pharm. Ana., 2014 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation", Taylor and francis, 2023 More
Tweet