Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study

Faculty	Pharmacy	Year:	2017
Type of Publication:	ZU Hosted	Pages:
Authors:
Journal:	Bioorganic & Medicinal Chemistry Letters ELSEVIER	Volume:

Keywords :	Quinazolinone-based rhodanine-3-acetic acids , potent aldose reductase
Abstract:	A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e

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