Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Bioorganic & Medicinal Chemistry Letters ELSEVIER Volume:
Keywords : Quinazolinone-based rhodanine-3-acetic acids , potent aldose reductase    
Abstract:
A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e
    
     
 
       

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