Design, synthesis and in-vitro antitumor activity of novel phthalazin-1,4-dione/chalcone hybrids and phthalazin-1,4-dione/pyrazoline hybrids

Faculty Pharmacy Year: 2015
Type of Publication: ZU Hosted Pages: 1154-1166
Authors:
Nermeen Awny Ahmed Mohamd
Journal: Journal of Chemical and Pharmaceutical Research JCPRC5 Volume:
Keywords : Design, synthesis , , in-vitro antitumor activity , , novel    
Abstract:
In continuation of our study of phthalazinones with antitumor activity, several new phthalazin-1,4-diones based on the structure of vatalanib (PTK787) were designed and synthesized. The cytotoxicity of the final compounds was tested in vitr
    
     
 
       

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