Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Bulletin of Faculty of Pharmacy Cairo University Elsevier Volume:
Keywords : Adenine , benzimidazole-based mimics , REP-3123 , antibacterial agents    
Abstract:
As part of our ongoing research efforts to develop new antibacterial agents acting on novel molecular targets, a series of twenty-two adenine and benzimidazole-based mimics of the lead compound REP-3123 was designed to target methionyl-tRNA
    
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

Department Related Publications

  • Osama Ibrahim Abdou Elsabagh, "Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors", Taylor & Francis Group, 2022 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives", wiley, 2017 More
  • Mahmoud Mohamed Mohamed Sebaee, "Rapid RP-HPLC Method for Simultaneous Estimation of Some Antidiabetics; Metformin, Gliclazide and Glimepiride in Tablets", ejchem.journals.ekb.eg, 2018 More
  • Kamel Abdelrehem Metwaly Bayomy, "Non-carboxylic analogues of aryl-propionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential", Elsevier, 2007 More
  • Mansour Alsayed Mansour Abokol, "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF CERTAIN QUINAZOLINE DERIVATIVES", The Chinese Pharmaceutical Journal Vol., 45, No. 2 pp. 109-114, 1993 More
Tweet