Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Bulletin of Faculty of Pharmacy Cairo University Elsevier Volume:
Keywords : Adenine , benzimidazole-based mimics , REP-3123 , antibacterial agents    
Abstract:
As part of our ongoing research efforts to develop new antibacterial agents acting on novel molecular targets, a series of twenty-two adenine and benzimidazole-based mimics of the lead compound REP-3123 was designed to target methionyl-tRNA
    
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

Department Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and biological activity of 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives", Elsevier, 2007 More
  • Kamel Abdelrehem Metwaly Bayomy, ". Synthesis, in-vitro Cytotoxicity, and a Preliminary Structure-Activity Relationship Investigation of Pyrimido[4,5-c]quinolin-1(2H)-ones", Wiley-Interscience, 2010 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Synthesis of New 1,3-Benzodiazine and 1,3,4-Benzotriazepine Derivatives for Biological Study " تشييد مشتقات جديدة من 1و3 بنزوديازين و1و3و4 بنزوتريازيبين وذلك للدراسة البيولوجية", 2024 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of New 1,3-Benzodiazine and 1,3,4-Benzotriazepine Derivatives for Biological Study " تشييد مشتقات جديدة من 1و3 بنزوديازين و1و3و4 بنزوتريازيبين وذلك للدراسة البيولوجية", 2024 More
  • Mansour Alsayed Mansour Abokol, "Synthesis of New 1,3-Benzodiazine and 1,3,4-Benzotriazepine Derivatives for Biological Study " تشييد مشتقات جديدة من 1و3 بنزوديازين و1و3و4 بنزوتريازيبين وذلك للدراسة البيولوجية", 2024 More
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