Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: synthesis and in vitro cytotoxic activity

Faculty Pharmacy Year: 2007
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: European Journal of Medicinal Chemistry Elsevier Volume:
Keywords : Pyrimido[4,5-c]quinolin-1(2H)-ones , , novel class , antimitotic agents: synthesis    
Abstract:
Several 2-amino-pyrimido[4,5-c]quinolin-1(2H)-ones variously substituted at positions 3, 5, and 9 were prepared from their corresponding lactones. The target compounds were investigated for in vitro cytotoxic activity against a panel of hum
    
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

Department Related Publications

  • Samy Megahed Ibrahiem Elsayed Sakr, "An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities", elsevier, 2025 More
  • Mansour Alsayed Mansour Abokol, "An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities", elsevier, 2025 More
  • Mostafa Khamies Sultan Farag, "An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities", elsevier, 2025 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities", elsevier, 2025 More
  • Mohammed Alhuseiny Abdelhamid Elsadek , "Exploring the binding sites of Staphylococcus aureus phenylalanine tRNA synthetase: A homology model approach", www.elsevier.com/locate/JMGM, 2017 More
Tweet