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6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase
Faculty
Science
Year:
2016
Type of Publication:
ZU Hosted
Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Staff Zu Site
Abstract In Staff Site
Journal:
European Journal of Medicinal Chemistry Elsevier Masson SAS.
Volume:
Keywords :
6-Methylpurine derived sugar modified nucleosides: Synthesis
Abstract:
Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine (Me
Author Related Publications
Abdullah Elsayed Abdullah Hassan, "A novel polystyrene/epoxy ultra‐fine hybrid fabric by electrospinning", Wiley, 2018
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Abdullah Elsayed Abdullah Hassan, "6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis and Evaluation of their Substrate Activity with Purine Nucleoside Phosphorylases", Elsevier, 2016
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Abdullah Elsayed Abdullah Hassan, "Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation", American Chemical Society, USA, 2016
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Abdullah Elsayed Abdullah Hassan, "Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA", Taylor & Francis, 2018
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Abdullah Elsayed Abdullah Hassan, "Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex", Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2018
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Department Related Publications
Ahmed Fouad Mohamed Elsayed Elfarargy, "design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives", EBSCO, 2017
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Sami Mahmoud Mohamed Ali Megharbel, "Spectroscopic, structural characterizations and antioxidant capacity of the chromium (III) niacinamide compound as a diabetes mellitus drug model", ELSEVIER, 2017
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Ahmed Diab Abdelghafar Khater, "Environmental factors affecting the corrosion behavior of reinforcing steel. II. Role of some anions in the initiation and inhibition of pitting corrosion of steel in Ca(OH)2 solutions", Elseiver, 2010
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Ahmed Diab Abdelghafar Khater, "Environmental factors affecting the corrosion behavior of reinforcing steel. IV. Variation in the pitting corrosion current in relation to the concentration of the aggressive and the inhibitive anions", Elseiver, 2010
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Ahmed Heussein Mostafa, "Studies on the Chemical Reactivity of Ethyl 4-sulfanyl-6-methyl-2-phenylpyrimidine- 5-carboxylate", Bentham Science Publishers Ltd., 2010
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