6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: European Journal of Medicinal Chemistry Elsevier Masson SAS. Volume:
Keywords : 6-Methylpurine derived sugar modified nucleosides: Synthesis    
Abstract:
Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine (Me
    
     
 
       

Author Related Publications

  • Abdullah Elsayed Abdullah Hassan, "A novel polystyrene/epoxy ultra‐fine hybrid fabric by electrospinning", Wiley, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis and Evaluation of their Substrate Activity with Purine Nucleoside Phosphorylases", Elsevier, 2016 More
  • Abdullah Elsayed Abdullah Hassan, "Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation", American Chemical Society, USA, 2016 More
  • Abdullah Elsayed Abdullah Hassan, "Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA", Taylor & Francis, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex", Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2018 More

Department Related Publications

  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Synthesis of high surface area γ-alumina by microwave irradiation process.", Journal of American Science, 2014 More
  • Fathi Ahmed Abdul Latif Yassin, "Synthesis and Reactions of 4- Cyano 5,6-(Di-2’-pyridyl)-3(2H)-Pyridazinones derivatives", جامعة القاهرة, 1991 More
  • Fathi Ahmed Abdul Latif Yassin, "dazinone Derivatives and Related compounds Part 3(1)Pyri some reactions of 4-cyano pyridazinthion", ألمانيا, 1991 More
  • Fathi Ahmed Abdul Latif Yassin, "Synthesis and reactions of 5-phenylpyrido-[3,2-d]-pyridazin-8(7H)-one derivatives", الهند, 2013 More
  • Mohamed Yousry Elsayed ebrahim, "Biomarkers charge transfer complexes of melamine with quinol and picric acid: Synthesis, spectroscopic, thermal, kinetic and biological studies", Elsevier, 2017 More
Tweet