6-Methylpurine derived sugar modified nucleosides: Synthesis and
in vivo antitumor activity in D54 tumor expressing M64V-Escherichia
coli purine nucleoside phosphorylase

Faculty	Science	Year:	2016
Type of Publication:	ZU Hosted	Pages:
Authors:	Abdullah Elsayed Abdullah Hassan Staff Zu Site Abstract In Staff Site
Journal:	European Journal of Medicinal Chemistry Elsevier Masson SAS.	Volume:

Keywords :	6-Methylpurine derived sugar modified nucleosides: Synthesis
Abstract:	Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine (Me

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