Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: Organic Letters American Chemical Society, USA Volume:
Keywords : Lithium Hexamethyldisilazane Transformation , Transiently Protected 4‑Aza/Benzimidazole    
Abstract:
Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58−88% yields. This strategy offers a much better choice
   
     
 
       

Author Related Publications

  • Abdullah Elsayed Abdullah Hassan, "A novel polystyrene/epoxy ultra‐fine hybrid fabric by electrospinning", Wiley, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis and Evaluation of their Substrate Activity with Purine Nucleoside Phosphorylases", Elsevier, 2016 More
  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase", Elsevier Masson SAS., 2016 More
  • Abdullah Elsayed Abdullah Hassan, "Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA", Taylor & Francis, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex", Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2018 More

Department Related Publications

  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Synthesis, Spectral, Antimicrobial, and Thermal Properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) Gliclazide Complexes1", , Russian Journal of General Chemistry, 2016 More
  • Mohamed Yousry Elsayed ebrahim, "Synthesis, Spectral, Antimicrobial, and Thermal Properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) Gliclazide Complexes1", , Russian Journal of General Chemistry, 2016 More
  • Sami Mahmoud Mohamed Ali Megharbel, "Synthesis, Spectral, Antimicrobial, and Thermal Properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) Gliclazide Complexes1", , Russian Journal of General Chemistry, 2016 More
  • Mohamed Yousry Elsayed ebrahim, "Synthesis, physicochemical characterization and anticancer screening of sulfa drug ruthenium complexes as anticancer agent", Journal of Molecular Liquids, 2016 More
  • Ayman AboulFotouh Gouda Sallem, "SPECTROPHOTOMETRIC METHODS BASED ON CHARGE TRANSFER COMPLEXATION REACTION FOR THE DETERMINATION OF SOME ANTIFUNGAL DRUGS IN PURE AND DOSAGE FORMS", Chemical Society of Ethiopia, 2016 More
Tweet