Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: Organic Letters American Chemical Society, USA Volume:
Keywords : Lithium Hexamethyldisilazane Transformation , Transiently Protected 4‑Aza/Benzimidazole    
Abstract:
Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58−88% yields. This strategy offers a much better choice
   
     
 
       

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