Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.

Faculty Medicine Year: 2014
Type of Publication: ZU Hosted Pages:
Authors:
Mohamed Abdulla Mohamed Atef Abdalla Alattar
Journal: Mol Cancer. Biomed central Volume:
Keywords : Targeting , prohibitin scaffold-CRAF kinase interaction , RAS-ERK-driven    
Abstract:
Abstract BACKGROUND: Robust ERK1/2 activity, which frequently results from KRAS mutation, invariably occurs in pancreatic ductal adenocarcinoma (PDAC). However, direct interference of KRAS signaling has not led to clinically successful dr
    
     
 
       

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