Synthesis and Biological Evaluation of Some N-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents

Faculty Pharmacy Year: 2013
Type of Publication: ZU Hosted Pages: 688–698
Authors:
Osama Ibrahim Abdou Elsabagh
Journal: Arch. Pharm. Chem. Life Sci. 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Volume:
Keywords : Synthesis , Biological Evaluation , Some N-Arylpyrazoles , Pyrazolo[3,4-d]pyridazines    
Abstract:
A series of 3,4-bis-chalcone-N-arylpyrazoles 3a–k was prepared from diacetyl pyrazoles 2a–e. The reaction of 2d and 2e with hydrazine hydrate gave pyrazolo[3,4-d]pyridazine derivatives 4a–b. Furthermore, the reaction of 2a–e with thiosemica
    
     
 
       

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