Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations

Faculty Pharmacy Year: 2008
Type of Publication: ZU Hosted Pages: 333–343
Authors:
Omnia Ahmed Emam Ismaiel
Journal: Journal of Chromatography B USA Volume:
Keywords : Monitoring phospholipids , assessment , , enhancement , ion suppression , , , APCI    
Abstract:
Biological matrix effects are a source of significant errors in both electrospray (ESI) and atmospheric pressure chemical ionization (APCI) LC/MS. Glycerophosphocholines (GPChos) and 2-lysoglycerophosphocholines (2-lyso GPChos) are known
    
     
 
       

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  • Omnia Ahmed Emam Ismaiel, "Non-extractive spectrophotometric determination of memantine HCl, clomipramine HCl and fluvoxamine maleate in pure form and in pharmaceutical products by ion-pair complex formation with rose Bengal.", ScienceDirect, 2020 More
  • Omnia Ahmed Emam Ismaiel, "Monitoring phospholipids for assessment of matrix effects in a liquid chromatography–tandem mass spectrometry method for hydrocodone and pseudoephedrine in human plasma", USA, 2007 More
  • Omnia Ahmed Emam Ismaiel, "Assessment of matrix effects and determination of niacin in human plasma using liquid–liquid extraction and liquid chromatography–tandem mass spectrometry", USA, 2008 More
  • Omnia Ahmed Emam Ismaiel, "Development of a Liquid Chromatography-Negative ESI-Tandem Mass Spectrometry Method for Ibuprofen with Minimization of Matrix Effects Associated with Phospholipids", USA, 2008 More
  • Omnia Ahmed Emam Ismaiel, "Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry", USA, 2010 More

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