Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization

Faculty Pharmacy Year: 2013
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: Molecular Cancer Therapeutics AACR publications Volume:
Keywords : Novel Inhibitors , Rad6 Ubiquitin Conjugating Enzyme:    
Abstract:
Protein ubiquitination is important for cell signaling, DNA repair, and proteasomal degradation, and it is not surprising that alterations in ubiquitination occur frequently in cancer. Ubiquitin-conjugating enzymes (E2) mediate ubiquitinati
    
     
 
       

Author Related Publications

  • Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016 More
  • Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance", Springer Nature., 2017 More

Department Related Publications

  • Mansour Alsayed Mansour Abokol, "SYNTHESIS AND PRELIMINARY TESTING OF SOME ANTHRANILIC ACID DERIVATIVES AS ANTIIFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS", Zag. J. Pharm. Sci., Vol. 2 No. 1. Pp 140-149 June, 1993 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation", Taylor and francis, 2023 More
  • Samar Saied Mahmoud Mohamed Elbaramawy, "Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation", Taylor and francis, 2023 More
  • Hend Kather Abdelhakem Elhamalawy, "Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation", Taylor and francis, 2023 More
  • Ahmed Samy Abdelsamad Abdelkhalek hilal, "The use of an RP-HPLC-UV method for the analysis of oxcarbazepine in the presence of its preservatives; stability studies and application to human plasma samples", Academia Kiado (Aki journals), 2023 More
Tweet